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FCE 28654
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FCE 28654图片
CAS NO:169474-77-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
FCE28654是一种水溶的酰基COA:胆固醇酰基转移酶(ACAT)抑制剂,在兔主动脉、肠和猴肝脏的微粒体中,抑制ACAT的活性,IC50值分别为2.55,1.08和5.69μM。
Cas No.169474-77-5
Canonical SMILESCC(C)C(C=CC=C1C(C)C)=C1NC(NCC2(C3=CC=C(OP(O)(O)=O)C=C3)O[C@H](C)[C@@H](C)O2)=O
分子式C25H35N2O7P
分子量506.53
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1].

FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1].

[1]. A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586.