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Paraxanthine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Paraxanthine图片
CAS NO:611-59-6
包装:10mg
市场价:714元

产品介绍
Paraxanthine,caffeine的代谢物,可通过刺激Ryanodine受体通道来抑制多巴胺能细胞的死亡。
Cas No.611-59-6
别名1,7-二甲基黄嘌呤
Canonical SMILESO=C(N1C)NC2=C(N(C)C=N2)C1=O
分子式C7H8N4O2
分子量180.17
溶解度DMF: 20 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL,Ethanol: 0.5 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase)[1].

[1]. Guerreiro S, et al. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008 Oct;74(4):980-9.