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Indatraline hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indatraline hydrochloride图片
CAS NO:96850-13-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
茚达曲林盐酸盐
Lu 19-005
产品介绍
Indatraline hydrochloride (Lu 19-005) 是一种非选择性单胺转运体抑制剂,可阻断神经递质的再摄取 (多巴胺血清素去甲肾上腺素),其疗效与可卡因相似。Indatraline hydrochloride 可用于抗抑郁的研究。Indatraline hydrochloride 诱导自噬,同时抑制细胞增殖。Indatraline hydrochloride 也可能指导自噬相关疾病如动脉粥样硬化或再狭窄的新化合物的开发。
生物活性

Indatraline hydrochloride (Lu 19-005) is a non-selectivemonoamine transporterinhibitor that blocks the reuptake of neurotransmitters (dopamine,serotonin, andnorepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride inducesautophagywhile simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1].

IC50& Target

monoamine transporter[1]

体外研究
(In Vitro)

Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1].
Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1].
Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1].

Western Blot Analysis[1]

Cell Line:HeLa cells
Concentration:0~5 μM
Incubation Time:24 hours
Result:Made the concentration-dependent conversion of LC3.

Immunofluorescence[1]

Cell Line:EGFP-LC3 stable cells
Concentration:1~10 μM
Incubation Time:24 hours
Result:EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm.
体内研究
(In Vivo)

Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells[1].

分子量

328.66

Formula

C16H16Cl3N

CAS 号

96850-13-4

中文名称

茚达曲林盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.