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Diclofensine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diclofensine图片
CAS NO:67165-56-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Ro 8-4650
产品介绍
Diclofensine(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。
生物活性

Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].

分子量

322.23

Formula

C17H17Cl2NO

CAS 号

67165-56-4

中文名称

双氮奋兴

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.