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MAO-IN-M30 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAO-IN-M30 dihydrochloride图片
CAS NO:64821-19-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
MAO-IN-M30 dihydrochloride 是一种口服活性,可通过血脑屏障的,脑选择性不可逆MAO-A(IC50=37 nM) 和MAO-B(IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
生物活性

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversibleMAO-A(IC50=37 nM) andMAO-B(IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potentiron chelatorandradical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cellapoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease[1][2][3].

IC50& Target[1]

MAO-A

37 nM (IC50)

MAO-B

57 nM (IC50)

体外研究
(In Vitro)

MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone[3].
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4].
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3].

Cell Viability Assay[3]

Cell Line:SH-SY5Y cells
Concentration:0.25 nM
Incubation Time:72 hours
Result:Significantly increased cell viability to ~90% after exposure to Dexamethasone.

Cell Viability Assay[4]

Cell Line:PC12 cells
Concentration:0-10 μM
Incubation Time:24 hours
Result:Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
体内研究
(In Vivo)

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6].

Animal Model:Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)[6]
Dosage:0.5, 2.5 mg/kg
Administration:P.o.; once daily for 14 consecutive days
Result:Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
分子量

299.20

性状

Solid

Formula

C14H16Cl2N2O

CAS 号

64821-19-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 2 mg/mL(6.68 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.3422 mL16.7112 mL33.4225 mL
5 mM0.6684 mL3.3422 mL6.6845 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。