CAS NO: | 209394-27-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
生物活性 | Ladostigil (TV-3326) is an orally active dual inhibitor ofcholinesteraseand brain-selectivemonoamine oxidase(MAO), withIC50s of 37.1 and 31.8 μM forMAO-BandAChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease[1][2]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Ladostigil (1-10 μM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults[2]. | ||||||||
体内研究 (In Vivo) | Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
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Clinical Trial | |||||||||
分子量 | 272.34 | ||||||||
Formula | C16H20N2O2 | ||||||||
CAS 号 | 209394-27-4 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |