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Sulfisoxazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfisoxazole图片
CAS NO:127-69-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂,对内皮素受体 A 和内皮素受体 B 的 IC50 值分别为 0.60 μM 和 22 μM。
Cas No.127-69-5
别名磺胺异恶唑; Sulfafurazole
化学名4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Canonical SMILESCC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
分子式C11H13N3O3S
分子量267.3
溶解度≥ 10.65mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2].

References:
[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
[2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998