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Sulfamethoxazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfamethoxazole图片
CAS NO:723-46-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Sulfamethoxazole (Ro 4-2130) 是一种磺胺类抑菌抗生素,用于细菌感染。
Cas No.723-46-6
别名磺胺甲恶唑; Ro 4-2130
化学名4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Canonical SMILESCC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N
分子式C10H11N3O3S
分子量253.28
溶解度≥ 7.75mg/mL in DMSO
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sulfamethoxazole (Ro 4-2130) is a sulfonamide bacteriostatic antibiotic. Sulfamethoxazole is being used for human and veterinary applications[1].

Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.

References:
[1]. Straub JO, et al. Aquatic environmental risk assessment for human use of the old antibiotic sulfamethoxazole in Europe. Environ Toxicol Chem. 2016 Apr;35(4):767-79.