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MAO-B-IN-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAO-B-IN-5图片
CAS NO:849909-77-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MAO-B-IN-5 是一种有效的、选择性和具有口服活性的MAO-B抑制剂,IC50值为 0.204 μM。MAO-B-IN-5 具有研究帕金森病 (PD) 的潜力。
生物活性

MAO-B-IN-5 is a potent, selective and orally activeMAO-Binhibitor with anIC50of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1].

IC50& Target

MAO-B

34.190 μM (IC50)

MAO-A

0.204 μM (IC50)

体外研究
(In Vitro)

MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with theIC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively[1].

体内研究
(In Vivo)

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].

CompoundRouteDose (mg/kg)Cmax(ng/mL)AUCt(ng·h/mL)T1/2(h)Vss (h)Cl (mL/min/kg)F (%)
D0iv18093470.371.1147.1/
po51632841.27//16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.[1].

Animal Model:SD rats[1]
Dosage:1, 5 mg/kg
Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:Showed oral bioavailability in rats (F=16.3%).
分子量

328.38

Formula

C19H21FN2O2

CAS 号

849909-77-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.