| 包装: | 1mg |
| 市场价: | 3224元 |
| 分子式 | C190H287N55O57 |
| 分子量 | 4253.7 |
| 溶解度 | Soluble to 1 mg/ml in Water |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Scrambled Neuropeptide Y (scNPY) was similarly synthesized and contains the same amino acids as NPY, but scNPY is in a random sequence, it was used as a control in the research in NPY [1]. The sequence of scNPY is SKPQRDANREPTRYAIYDYSNPDIELHYLRPAYALG-NH2 [2]. Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous system. It modulates a variety of physiological processes, e.g. the central regulation of vasoconstriction, memory retention and food intake, and the regulation of circadian rhythm [2]. Scrambled NPY peptide treatment had no effect on VEGF expression in 4T1 cells. Previous treatment with scrambled NPY at concentrations ranging from 10–10 to 10–7 M made conditioned media from 4T1 cells show no difference in the number of complete endothelial networks or branch points versus control in endothelial tube formation assays [3]. In trimethyltin-treated (TMT-treated) rats, treatment with scrambled NPY for 24 h made the expression of Bdnf, NpyR, neurogenic and antiapoptotic genes comparable to that of saline-injected animals (without significant differences) [4]. In TMT-treated rats, both saline and scNPY showed no significant modulation (p>0.05) in the expression levels of Npy1R, Npy2R and Npy5R [5]. References: |
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