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PAF(C16)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PAF(C16)图片
CAS NO:74389-68-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
PAF (C16) (PAF (C16)) 是一种磷脂介质，是一种血小板活化因子和 PAF G 蛋白偶联受体 (PAFR) 的配体。
Cas No.74389-68-7
别名Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂,Platelet-activating Factor C-16
化学名(R)-2-acetoxy-3-(hexadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
Canonical SMILES[O-][P@@](OCC[N+](C)(C)C)(OC[C@@H](COCCCCCCCCCCCCCCCC)OC(C)=O)=O
分子式C26H54NO7P
分子量523.68
溶解度10 mg/ml in DMF,10 mg/ml in DMSO,10 mg/ml in Ethanol,PBS (pH 7.2): 25 mg/ml,30 mg/ml in Water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.[1] It is a potent mediator of neutrophil migration,[2] and the production of reactive oxygen species, and IL-6 in human macrophages.[3],[4] It is a more potent mediator of platelet aggregation than PAF C-18.[5] Pathological processes involving PAF include necrotizing enterocolitis,[6] inflammation, asthma, and allergy.[7]

Reference:
[1]. Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990).
[2]. Carolan, E.J., and Casale, T.B. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. Journal of Immunology 145, 2561-2565 (1990).
[3]. Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochemical and Biophysical Research Communications 156, 1293-1301 (1988).
[4]. Thivierge, M., and Rola-Pleszczynski, M. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Journal of Allergy and Clinical Immunology 90, 796-802 (1992).
[5]. Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. Journal of Lipid Mediators 4, 299-308 (1991).
[6]. Wang, H., Tan, X.D., Qu, X.W., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatric Research 42, 597-603 (1997).
[7]. Sturk, A., Wouter Ten Cate, J., Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Advances in Lipid Research 23, 219-276 (1989).