CAS NO: | 258279-04-8 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Endogenous agonist for ghrelin receptor (GHS-R1a)
Cas No. | 258279-04-8 |
别名 | 来诺瑞林 |
分子式 | C149H249N47O42 |
分子量 | 3370.9 |
溶解度 | Soluble in Water |
储存条件 | Desiccate at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
文献引用 | |
产品描述 | Ghrelin is a specific endogenous ligand for the GHS receptor which can stimulate strong increase in circulating GH levels both in vitro and in vivo in a dose-dependent manner, Human acylated ghrelin is the major active form that can cross the blood-brain barrier, and has an effection on the activity of arcute neurones with a much stronger affinity (IC50, 0.3×10-9M) than GHSR antagonist (D-Lys3)-GHRP-6 (IC50, 0.9×10-6M)[1]. Ghrelin has effects in stimulating appetite, increasing secretion of GH and hypo-catabolism, improvement of gastrointestinal motility, increasing cardiac output, improvement of pulmonary function and anti-inflammatory effect. Clinical applications of ghrelin in total gastrectomy, esophagectomy and neoadjuvant chemotherapy can stimulate food intake, improve guality of life scores and minimize adverse events. Recently, ghrelin as a effective approach in the management of anorexia nervosa[2],cachexia[3], BW[4] and appetite loss[5], systemic inflammatory response[6]and cancer[7]. In conclusion, ghrelin is a promising candidate for treating catabolic states and enhancing immune function in cachexia or acquired immunodeficiency syndrome, as well as for treating eating disorders such as obesity and anorexia nervosa. References: |