| In Vitro | In vitro activity: Cetilistat inhibits rat and human pancreatic lipase activity with IC50 of 54.8 nM and 5.95 nM, respectively.
Kinase Assay:
Cell Assay: |
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| In Vivo | Cetilistat reduces intestinal fat absorption in rats and decreases energy intake without CNS side effects. Cetilistat ameliorates obesity and hyperlipidemia in DIO rats, a plausible animal model of the most common type of human obesity. |
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| Animal model | Male nine-week-old SD rats |
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| Formulation & Dosage | Formulated in 0.5 % methylcellulose suspension; 3, 10, 30, or 100 mg/kg; P.O. |
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| References | Horm Metab Res. 2008 Aug;40(8):539-43. |
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