Vandetanib-d6 (ZD6474-d6) is the deuterium labeled Vandetanib. Vandetanib (D6474) is a potent, orally active inhibitor ofVEGFR2/KDRtyrosine kinase activity (IC₅₀=40 nM). Vandetanib also has activity versus the tyrosine kinase activity ofVEGFR3/FLT4(IC₅₀=110 nM) andEGFR/HER1(IC₅₀=500 nM)^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

481.39

C₂₂H₁₈D₆BrFN₄O₂

1174683-49-8

凡德他尼 d6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.