Vandetanib-d4

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Vandetanib-d4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1215100-18-7

包装与价格：

包装	价格(元)
2.5mg	电议
1mg	电议
5mg	电议
10mg	电议

产品名称

凡德他尼 d4

产品介绍

Vandetanib-d4 (ZD6474-d4) 是 Vandetanib 的氘代物。Vandetanib (ZD6474) 是一种有效的，具有口服活性的VEGFR2/KDR酪氨酸激酶抑制剂 (IC₅₀=40 nM)。Vandetanib 也抑制VEGFR3/FLT4(IC₅₀=110 nM) 和EGFR/HER1(IC₅₀=500 nM)。

生物活性	Vandetanib-d4 (ZD6474-d4) is the deuterium labeled Vandetanib. Vandetanib (ZD6474) is a potent, orally active inhibitor ofVEGFR2/KDRtyrosine kinase activity (IC₅₀=40 nM). Vandetanib also has activity versus the tyrosine kinase activity ofVEGFR3/FLT4(IC₅₀=110 nM) andEGFR/HER1(IC₅₀=500 nM)^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
分子量	479.38
Formula	C₂₂H₂₀D₄BrFN₄O₂
CAS 号	1215100-18-7
中文名称	凡德他尼 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.