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VEGFR2-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VEGFR2-IN-1图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
VEGFR2-IN-1 是一种有效的选择性VEGFR2抑制剂 (IC50=19.8 nM)。VEGFR2-IN-1 通过凋亡激活和抑制VEGFR2的表达来抑制细胞的增殖和迁移。
生物活性

VEGFR2-IN-1 is a potent and selectiveVEGFR2inhibitor (IC50=19.8 nM). VEGFR2-IN-1 inhibits cell proliferation and migration throughapoptosisactivation andVEGFR2inhibition[1].

IC50& Target

VEGFR2

19.8 nM (IC50)

体外研究
(In Vitro)

VEGFR2-IN-1 (compound 17; 0.1, 1, 10, 100 μM; 48 hours) shows an effective and selective agent against MCF-7 (IC50=1.18 μM), MDA-MB-231 (IC50=10.49 μM), MCF-10A (IC50=24.76 μM) cells[1]. VEGFR2-IN-1 (MCF-7 cells; 48 hours) induces cell cycle arrest at the G1 and S-phases[1]. VEGFR2-IN-1 (MCF-7 cells) shows the upregulation of pro-apoptotic genes (p53, Bax, caspases-3, caspases-9) and downregulation of antiapoptotic gene (Bcl-2)[1].

Cell Cytotoxicity Assay[1]

Cell Line:MCF-7, MDA-MB-231, MCF-10A cells
Concentration:0.1, 1, 10, 100 μM
Incubation Time:48 hours
Result:Exhibited an effective and selective agent against MCF-7 (IC50=1.18 μM), MDA-MB-231 (IC50=10.49 μM), MCF-10A (IC50=24.76 μM) cells.
体内研究
(In Vivo)

VEGFR2-IN-1 (4.2 mg/kg; i.p.; once a day for 7 days) shows anticancer activity with an improvement of hematological, biochemical parameters[1]. Animal Model: Male Swiss albino mice, 21-28 g (Xenograft model)[1].

Animal Model:Male Swiss albino mice, 21-28 g (Xenograft model)[1]
Dosage:4.2 mg/kg
Administration:i.p.; once a days; 7 days
Result:Showed anticancer activity by having a tumor inhibition ratio of 54.2% with an improvement of hematological, biochemical parameters.
分子量

398.48

Formula

C22H18N6S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.