IC₅₀s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties^[1].

AAL993 suppresses HIF-1α expression through ERK inhibition without affecting Akt phosphorylation^[2].

AAL993 (compound 5) potently inhibits VEGF-induced angiogenesis in an implant model, with an ED₅₀value of 7 mg/kg^[1].
In B16 melanoma xenograft model, AAL993 (24-100 mg/kg; p.o.; daily; for 14days) inhibits both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases^[1].

371.36

C₂₀H₁₆F₃N₃O

269390-77-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.