GW768505A free base is a potent dual inhibitor ofVEGFR2 (KDR)andTie-2, with a pIC₅₀of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity^[1]。

GW768505A free base has inhibition for cancer cells growth in NCI-60 panel screening^[2].
GW768505A free base is an inhibitor of KDR and TIE2, shows potent inhibition (71–88% inhibition at 100 nM) of the tropomysin-related kinases TRKA, TRKB and TRKC^[2].

537.47

C₂₇H₁₉F₄N₅O₃

501693-25-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.