ZM323881 is a potent and selectiveVEGFR2inhibitor with anIC₅₀of less than 2 nM.

ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC₅₀>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC₅₀=8 nM) and VEGFR2 tyrosine phosphorylation^[1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM^[2].

375.40

C₂₂H₁₈FN₃O₂

193001-14-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.