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Rubropunctatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rubropunctatin图片
CAS NO:514-67-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎,免疫抑制和抗氧化作用,还具有抗肿瘤活性。
生物活性

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts ofMonascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity[1][2][3].

体外研究
(In Vitro)

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells[1].
Rubropunctatin (0.75-8.0 μg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity[2].

Cell Viability Assay[1]

Cell Line:BGC-823 and GES-1cells
Concentration:1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time:24 hours
Result:Decreased the viability of BGC-823 cells with an IC50of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis[1]

Cell Line:BGC-823 cells
Concentration:0, 5, 10, 30 μM
Incubation Time:0, 6, 12, 24 hours
Result:Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
体内研究
(In Vivo)

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice[1].
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50of 0.11 mg/ear[3].

Animal Model:Male nude mice (5 weeks) are inoculated with BGC-823 cells[1]
Dosage:8, 32 mg/kg
Administration:I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.
分子量

354.40

Formula

C21H22O5

CAS 号

514-67-0

结构分类
  • Ketones, Aldehydes, Acids
来源

Monascus purpureus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.