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Cyclic di-GMP(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclic di-GMP(sodium salt)图片
CAS NO:2222132-40-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cyclic di-GMP（钠盐）是一种 STING 激动剂和细菌第二信使，可协调细菌生长和行为的不同方面，包括运动性、毒力、生物膜形成和细胞周期进程。 Cyclic di-GMP（钠盐）具有抗癌细胞增殖活性，还诱导 CD4 受体表达升高和细胞周期停滞。环状二GMP（钠盐）可用于癌症研究。
Cas No.2222132-40-1
别名c-di-GMP, Cyclic diguanylate, 3',5'-Cyclic diguanylic acid
化学名guanylyl-(3'→5')-3'-guanylic acid, cyclic nucleotide, disodium salt
Canonical SMILESO=C1NC(N)=NC2=C1N=CN2[C@@H]([C@@H]3O)O[C@@]([H])([C@]3(OP([O-])(OC[C@]([H])([C@]4(O5)[H])O[C@H]([C@@H]4O)N6C(N=C(N7)N)=C(N=C6)C7=O)=O)[H])COP5([O-])=O.[Na+].[Na+]
分子式C20H22N10O14P2o2Na
分子量734.4
溶解度1mg/mL in water
储存条件Store at -80℃, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.[1],[2] In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 μM), leading to activation of the innate immune system.[3],[4] It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP, 3’2’-cGAMP, 3’3’-cGAMP, and 2’2’-cGAMP.

Reference:
[1]. Romling, U., Galperin, M.Y., and Gomelsky, M. Cyclic di-GMP: The first 25 years of a universal bacterial second messenger Microbiology and Molecular Biology Reviews 77(1), 1-52 (2013).
[2]. Martínez, L.C., and Vadyvaloo, V. Mechanisms of post-transcriptional gene regulation in bacterial biofilms Front.Cell.Neurosci. 4(38), 1-15 (2014).
[3]. Schaap, P. Cyclic di-nucleotide signaling enters the eukaryote domain IUBMB Life 65(11), 897-903 (2013).
[4]. Zhang, X., Shi, H., Wu, J., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING Mol. Cell 51(2), 226-235 (2015).