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Pseudocoptisine chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pseudocoptisine chloride图片
CAS NO:30044-78-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
盐酸异黄连碱
Isocoptisine chloride
产品介绍
Pseudocoptisine (Isocoptisine) chloride 是一种具有苄基异喹啉骨架的季生物碱。Pseudocoptisine chloride 可抑制乙酰胆碱酯酶(AChE)活性,IC50为 12.8 μM。具有抗发炎和健忘作用。
生物活性

Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibitsacetylcholinesterase (AChE)activity with anIC50of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].

体外研究
(In Vitro)

Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells[2].
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions[1].
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells[1].

体内研究
(In Vivo)

The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test[1].

分子量

355.77

性状

Solid

Formula

C19H14ClNO4

CAS 号

30044-78-1

中文名称

盐酸异黄连碱

结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
  • Alkaloids
  • Piperidine Alkaloids
来源
  • Plants
  • Papaveraceae
  • Corydalis turtschaninoviiBess.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 1 mg/mL(2.81 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.8108 mL14.0540 mL28.1080 mL
5 mM---------
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。