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Cinnabarinic acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cinnabarinic acid图片
CAS NO:606-59-7
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍

Cinnabarinic acid 是一种 mGlu4 的特异性正构激动剂，通过与 mGlu4 的谷氨酸结合口袋的残基相互作用，对其他 mGlu 受体没有活性。

Cas No.606-59-7
别名朱砂精酸
化学名2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Canonical SMILESO=C1C(N)=C(C(O)=O)C2=NC3=C(C(O)=O)C=CC=C3OC2=C1
分子式C14H8N2O6
分子量300.22
溶解度DMSO: 25 mM (warmed)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Cinnabarinic acid is a phenoxazinone produced by the oxidative dimerization of 3-hydroxyanthranilic acid (3-HAA) as part of the metabolism of tryptophan in the kynurenic pathway.[1],[2] It acts as a partial receptor agonist of the metabotropic glutamate receptor 4 (mGlu4), effective at 100 μM, with no activity at other mGlu receptor subtypes.[3] 3-HAA does not affect mGlu receptors, including mGlu4. Cinnabarinic acid induces apoptosis of T cells at 300-500 μM, a potency some ten times that of 3-HAA.[4]

Reference:
[1]. Subba Rao, P.V., and Vaidyanathan, C.S. Enzymic conversion of 3-hydroxyanthranilic acid into cinnabarinic acid. Partial purification and properties of rat-liver cinnabarinate synthase. Biochemistry Journal 99(2), 317-322 (1966).
[2]. Stone, T.W., Stoy, N., and Darlington, L.G. An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013).
[3]. Fazio, F., Lionetto, L., Molinaro, G., et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology 81(5), 643-656 (2012).
[4]. Hiramatsu, R., Hara, T., Akimoto, H., et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Journal of Cellular Biochemistry 103(1), 42-53 (2008).