Polygalacic acid

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Polygalacic acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

22338-71-2

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品名称

毛果一枝黄花皂苷元G

产品介绍

Polygalacic acid 毛果一枝黄花皂苷元 G 是一种三萜，是从远志Polygala tenuifolia Willd根中分离出来的。 Polygalacic acid 抑制MMP表达。 Polygalacic acid 可以用于骨关节炎 (OA) 相关研究。 Polygalacic acid 对认知障碍有显着的神经保护作用，PA 通过抑制乙酰胆碱酯酶 (AChE) 活性，增加胆碱乙酰转移酶(ChAT) 活性，提高海马和额皮质中的乙酰胆碱 (Ach) 水平来提高胆碱能系统反应性。

生物活性

Polygalacic acid, is a triterpene, isolated from the root ofPolygala tenuifolia Willd. Polygalacic acid inhibitsMMPexpression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment^[1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex^[2].

IC₅₀& Target

AChE

体外研究
(In Vitro)

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner^[1].
Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid^[1].

RT-PCR^[1]

Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time:	24 hours
Result:	Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis^[1]

Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time:	6 hours
Result:	Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

分子量

504.70

性状

Solid

Formula

C₃₀H₄₈O₆

CAS 号

22338-71-2

中文名称

毛果一枝黄花皂苷元G

结构分类

Terpenoids
Triterpenes

来源

Plants
Polygalaceae
Polygala tenuifoliaWilld.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(99.07 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9814 mL	9.9069 mL	19.8138 mL
5 mM	0.3963 mL	1.9814 mL	3.9628 mL
10 mM	0.1981 mL	0.9907 mL	1.9814 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。