6-Acetylnimbandiol

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6-Acetylnimbandiol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1281766-66-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

6-O-Acetylnimbandiol

产品介绍

6-Acetylnimbandiol (6-O-Acetylnimbandiol) 是一种无细胞毒性的tyrosinase抑制剂 (IC₅₀=69.85 μM)，能有效抑制黑色素的生成和MITF的表达。6-Acetylnimbandiol 可用于黑色素瘤的研究。

生物活性

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxictyrosinaseinhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production andMITFexpression. 6-Acetylnimbandiol can be used in melanoma research^[1].

IC₅₀& Target^[1]

Tyrosinas

69.85 μM (IC₅₀)

体外研究
(In Vitro)

6-Acetylnimbandiol (10, 30, 100 μM; 48 h) shows antimelanogenic activity in B16 melanoma cells^[1].
6-Acetylnimbandiol (50, 100 μM; 48 h) exerts melanogenesis inhibition by inhibiting expression of MITF, tyrosinase, TRP-1, and TRP-2 in B16 melanoma cells^[1].

Cell Viability Assay^[1]

Cell Line:	B16 melanoma cells
Concentration:	10, 30, 100 μM
Incubation Time:	48 h
Result:	Exhibited potent melanogenesis-inhibitory effect with 22.9% melanin content at 100 μM.

Western Blot Analysis^[1]

Cell Line:	B16 melanoma cells
Concentration:	50, 100 μM
Incubation Time:	48 h
Result:	Inhibited tyrosinase with an IC₅₀value of 69.85 μM.

分子量

498.56

Formula

C₂₈H₃₄O₈

CAS 号

1281766-66-2

结构分类

Terpenoids
Diterpenoids

来源

Plants
Meliaceae
Azadirachta indicaA. Juss.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.