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Crocin-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Crocin-4图片
CAS NO:55750-86-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Crocin-4,一种类胡萝卜素,是有效和可透过血脑屏障的抗氧化剂。Crocin-4 可以抑制 Aβ 原纤维在脑中的聚集和伴随沉积。Crocin-4 可用于阿尔茨海默症的研究。Crocin-4 还具有抗肿瘤和抗炎活性。
生物活性

Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities[1][2][3].

体外研究
(In Vitro)

Crocin-4 (0.1-1000 μM; 24-72 h) do not compromise cell viability of neuron-like cells[1].
Crocin-4 (1 mM; 72 h) reduces total PSEN1, PSEN1 and PSEN2 complexes, BACE1, APP-C99 and sAPPα, while it increases PSEN1-CTF and PSEN2 in SH-SY5Y-APP cells[1].
Crocin-4 (1 mM; 72 h) suppresses GSK3β and ERK1/2 kinases in PC12-htau cells, and significantly reduces the levels and phosphorylation of tau on the pThr231 and pSer199/Ser202 epitopes[1].

Western Blot Analysis[1]

Cell Line:Differentiated SH-SY5Y-APP cells
Concentration:1 mM
Incubation Time:72 hours
Result:Significantly reduced total PSEN1 by 19%, and the PSEN1 and PSEN2 complexes by 81 and 65%, while it increased PSEN1-CTF (26%) and PSEN2 (43%).
The key molecules of the amyloidogenic pathway, BACE1 and APP-C99 were significantly reduced by 20 and 28%, respectively.
The non-amyloidogenic pathway product sAPPα was also reduced, by 44%, while APP-C83 remained unaltered.

Western Blot Analysis[1]

Cell Line:Differentiated PC12-htau cells
Concentration:1 mM
Incubation Time:72 hours
Result:Significantly reduced total tau levels (by 32%) and tau phosphorylation (pThr231 and pSer199/Ser202-tau by 22 and 75%, respectively).
Downregulates the active and inactive forms of GSK3β (total GSK3β by 34%, pSer9-GSK3β by 30%) and ERK1/2 (total ERK2 by 37%, pERK1 by 40%, pERK2 by 50%).
体内研究
(In Vivo)

Crocin-4 (50 mg/kg; i.p.) is capable of crossing the Blood Brain Barrier (BBB) and build up levels in the mouse brain[3].

分子量

504.57

Formula

C27H36O9

CAS 号

55750-86-2

结构分类
  • Terpenoids
  • Diterpenoids
来源
  • Plants
  • Iridaceae
  • Crocus sativusLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.