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Myristoleic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Myristoleic Acid图片
CAS NO:544-64-9
包装:100mg
市场价:6500元

产品名称
肉豆蔻酸
肉豆蔻油酸
产品介绍
Myristoleic acid 是Serenoa repens提取物中的一种细胞毒性成分,可诱导人前列腺细胞的凋亡和坏死。
生物活性

Myristoleic acid, a cytotoxic component in the extract fromSerenoa repens, inducesapoptosisand necrosis in human prostatic LNCaP cells[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells[1].
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation[2].

Cell Proliferation Assay[1]

Cell Line:Human prostatic carcinoma LNCaP cells.
Concentration:0, 50, 100, 150, 200, 250 μg/mL.
Incubation Time:24 h.
Result:When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively.
体内研究
(In Vivo)

Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice[2].

Animal Model:C57BL/6 mice at 5 weeks[2].
Dosage:0.2, 2 mg/kg
Administration:IP every 24 h for 4 days.
Result:Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner.
分子量

226.36

性状

Liquid

Formula

C14H26O2

CAS 号

544-64-9

结构分类
  • Ketones, Aldehydes, Acids
来源
  • Plants
  • Palmae
  • Serenoa repens

enterococci

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
In solvent-80°C6 months
-20°C1 month