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Estetrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estetrol图片
CAS NO:15183-37-6
包装与价格:
包装价格(元)
500µg电议
1mg电议
5mg电议

产品介绍
Estetrol 是一种仅在怀孕期间由人类胎儿肝脏合成的天然雌激素,是一种选择性核雌激素受体调节剂。
Cas No.15183-37-6
别名雌四醇
化学名estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol
Canonical SMILESOC1=CC(CC[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@@H]4O)=C3C=C1
分子式C18H24O4
分子量304.4
溶解度5mg/mL in ethanol, 20mg/mL in DMSO, 30mg/mL in DMF
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).[1],[2] In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.[1],[2]

Reference:

[1]. Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E. Estetrol review: Profile and potential clinical applications Climacteric. 11(Suppl 1), 47-58 (2008).
[2]. Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton Front.Endocrinol.(Lausanne) 5(80), 1-8 (2014).