Gitogenin

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Gitogenin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

511-96-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
20mg	电议
50mg	电议
100mg	电议

产品介绍

Gitogenin 是从Tribulus longipetalus整株中分离出来的一种天然类固醇，是 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂，其IC₅₀值分别为 0.69 μM (使用三氟拉嗪为底物) 和 37.2 μM，并且不抑制人类主要细胞色素 P450 亚型的活性。

生物活性

Gitogenin is a natural steroid isolated from the whole plant ofTribulus longipetalus. Gitogenin is a selective inhibitor ofUDP-glucuronosyltransferase 1A4 (UGT1A4)and enzymeα-glucosidasewithIC₅₀values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major humancytochrome P450isoforms^[1]^[2].

IC₅₀& Target

IC50: 0.69 μM (UDP-glucuronosyltransferase 1A4)^[1]; IC50: 37.2 μM (α-glucosidase)^[2]

体外研究
(In Vitro)

When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with anIC₅₀value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, theIC₅₀value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, theIC₅₀value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with anIC₅₀value of 22.0 μM^[1].

体内研究
(In Vivo)

Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL)^[3].

分子量

432.64

性状

Solid

Formula

C₂₇H₄₄O₄

CAS 号

511-96-6

结构分类

Steroids

来源

Plants
Zygophyllaceae
Tribulus terresterLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 1.85 mg/mL(4.28 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3114 mL	11.5570 mL	23.1139 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。