CAS NO: | 4846-19-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibitsCYP2D6withIC50andKiof 3.76 and 2.34 μM, respectively. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent Kivalues of 2.34 μM[1]. | ||||||||||||||||
分子量 | 281.35 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H19NO2 | ||||||||||||||||
CAS 号 | 4846-19-9 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(355.43 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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