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Chlorfortunone A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorfortunone A图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Chlorfortunone A 是一种新的倍半萜类二聚体,可从Chloranthus fortunei的根中分离得到。Chlorfortunone A 能够抑制细胞转化生长因子 (TGF) β 的活性。
生物活性

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots ofChloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity[1].

体外研究
(In Vitro)

Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker[1].

Western Blot Analysis[1]

Cell Line:MDA-MB-231 cells
Concentration:10, 20, 40 μM
Incubation Time:4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
Result:Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.

Immunofluorescence[1]

Cell Line:MDA-MB-231 cells
Concentration:25 μM
Incubation Time:48 hours
Result:Significantly downregulated the expression of vimentin.
分子量

490.63

Formula

C31H38O5

结构分类
  • Terpenoids
  • Sesquiterpenes
来源
  • Plants
  • Chloranthaceae
  • Chloranthus fortunei(A. Gray) Solms-Laub
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.