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Famciclovir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Famciclovir图片
CAS NO:104227-87-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议

产品介绍
泛昔洛韦 (BRL 42810) 是一种具有口服活性的核苷类似物。
Cas No.104227-87-4
别名泛昔洛韦; BRL 42810
化学名[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
Canonical SMILESCC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
分子式C14H19N5O4
分子量321.33
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Famciclovir is an oral prodrug of penciclovir [1].

Famciclovir is an oral prodrug of anti- herpesvirus drug penciclovir since penciclovir is poorly absorbed when given orally to rodents. Famciclovir is a diester derivative of 6-deoxy-penciclovir. It can be quickly absorbed and converted to the antiviral drug efficiently both in rat tissues and fluids and in human tissues and fluids. Besides that, famciclovir is relatively stable in the duodenal contents and can give consistent levels of penciclovir in blood. Currently, famciclovir is approved to be used for the treatment of herpes zoster, herpes labialis, genital herpes in immunocompetent adult patients and HSV in immunocompromised adults [1, 2].

References:
[1] Hodge R A V, Sutton D, Boyd M R, et al. Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl) guanine; penciclovir]. Antimicrobial agents and chemotherapy, 1989, 33(10): 1765-1773.
[2] Sáez-Llorens X, Yogev R, Arguedas A, et al. Pharmacokinetics and safety of famciclovir in children with herpes simplex or varicella-zoster virus infection. Antimicrobial agents and chemotherapy, 2009, 53(5): 1912-1920.