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Tricetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tricetin图片
CAS NO:520-31-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品名称
三粒小麦黄酮
产品介绍
Tricetin 是一种有效的竞争性Keap1-Nrf2蛋白相互作用 (PPI) 抑制剂。Tricetin 作用于帕金森病模型,通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡 (apoptosis) 通路来保护 6-OHDA 诱导的神经毒性。
生物活性

Tricetin is a potent competitive inhibitor of theKeap1-Nrf2Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependentapoptosispathway[1].

体外研究
(In Vitro)

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors[1].
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis[1].
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38[1].

Cell Viability Assay

Cell Line:SH-SY5Y cells
Concentration:20, 40, and 80 μM
Incubation Time:Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h
Result:Significantly increased 6-OHDA-induced SH-SY5Y cells viability.

Western Blot Analysis

Cell Line:SH-SY5Y cells
Concentration:80 μM
Incubation Time:1, 2 and 4 h
Result:Markedly decreased the expressions of p-JNK and p-p38.
分子量

302.24

性状

Solid

Formula

C15H10O7

CAS 号

520-31-0

中文名称

三粒小麦黄酮

结构分类
  • Flavonoids
  • Flavonols
来源
  • Plants
  • Cupressaceae
  • Thuja occidentalisLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month