CAS NO: | 6246-46-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Ursolic acid, a naturally occurring triterpenoid, induces theapoptosisof humancancercells through multiple signaling pathways. In vitro: Ursolic acid is important in the induction ofapoptosisvia AKT/NF-κB signaling suppression in T24 human bladdercancercells and this occurs in a dose-dependent manner. Thus,AktandNF-κBare potential targets for bladdercancertherapy and ursolic acid may serve as a naturally-occurring candidate drug for the prevention and treatment of bladdercancer.[1] Ursolic acid induceapoptosisvia inhibition ofNF-κBinducedBCl-2mediated anti-apoptotic pathway leading to activation of p53 induced and caspase-3 mediated pro-apoptotic pathways.[2] In vivo: UA significantly suppressed prostate tumor growth in nude mice without any significant decrease in body weight. The systemic bioavailability of UA in serum samples obtained from nude mice. UA was detected in all serum samples 24 h after last injection. Systemic bioavailability of UA was in nanogram range and metabolites of UA were not detected in the samples. These results indicate that UA is well absorbed in the mouse peritoneum and supports the role of UA as a potent compound for chemoprevention and therapy of prostatecancer. [3] | ||||||||||||||||
分子量 | 454.68 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C30H46O3 | ||||||||||||||||
CAS 号 | 6246-46-4 | ||||||||||||||||
中文名称 | 熊果酮酸 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(109.97 mM;ultrasonic and warming and heat to 80℃) H2O : 1 mg/mL(2.20 mM;ultrasonic and warming and heat to 80℃) 配制储备液
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以下溶剂前显示的百
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