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LPA2 antagonist 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LPA2 antagonist 1图片
CAS NO:1017606-66-4
包装与价格:
包装价格(元)
10mM 1 mL in DMSO电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LPA2 拮抗剂 1 是一种 LPA2 拮抗剂,IC50 为 17 nM。
Cas No.1017606-66-4
化学名(S)-N-(1-(4-((3,4-dichlorophenyl)sulfonyl)piperazin-1-yl)propan-2-yl)-7-methylthieno[3,2-d]pyrimidin-4-amine
Canonical SMILESCC1=CSC2=C1N=CN=C2N[C@@](CN3CCN(S(C4=CC(Cl)=C(Cl)C=C4)(=O)=O)CC3)([H])C
分子式C20H23Cl2N5O2S2
分子量500.46
溶解度≥ 19.1mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.

LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner. LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA in a doses dependent manner[1].

References:
[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.