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Guanfacine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guanfacine图片
CAS NO:29110-47-2
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Guanfacine 是一种口服活性的去甲肾上腺素 α2A 激动剂,对 α2A 受体亚型具有高选择性。
Cas No.29110-47-2
别名胍法辛
化学名N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
Canonical SMILESC1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
分子式C9H9Cl2N3O
分子量246.09
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].

References:
[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403.
[2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.