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Delphinidin-3-sambubioside chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Delphinidin-3-sambubioside chloride图片
CAS NO:53158-73-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Dp3‐Sam chloride
产品介绍
Delphinidin-3-sambubioside (Dp3-Sam) chloride 一种具有口服活性的花青素,具有抗炎活性。Delphinidin-3-sambubioside chloride 抑制 LPS 诱导的炎症因子释放。Delphinidin-3-sambubioside chloride 还可以减轻 HFD 大鼠的肝脏脂质积累。Delphinidin-3-sambubioside chloride 可以从Hibiscus sabdariffa L.中分离出来。
生物活性

Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated fromHibiscus sabdariffa L.[1][3].

体外研究
(In Vitro)

Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50of 75 μM[2].
Delphinidin-3-sambubioside chloride (100-200 μg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2].

Western Blot Analysis[1]

Cell Line:RAW264.7 cells
Concentration:50, 100, 200 μM
Incubation Time:30 min
Result:Suppressed the degradation of IκB, and the phosphorylation of p65.
体内研究
(In Vivo)

Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3].

Animal Model:Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body,灌胃,每日一次,持续八周) 减少 HFD 大鼠的脂质积累[3]
Dosage:15 μmol/kg
Administration:Intraperitoneal injection (i.p.), for 4 days.
Result:Reduced the LPS-induced paw thickness.
Decreased the edema by 89.3%.
Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
Animal Model:HFD-fed rats[3]
Dosage:30 mg/kg
Administration:Oral gavage, daily for eight weeks.
Result:Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
分子量

632.95

Formula

C26H29ClO16

CAS 号

53158-73-9

结构分类
  • Flavonoids
  • Other Flavonoids
来源
  • Plants
  • Malvaceae
  • Hibiscus sabdariffaLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.