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Clemastanin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clemastanin B图片
CAS NO:112747-98-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
直铁线莲宁B
产品介绍
Clemastanin B 是一种木质素,通过抑制病毒增殖、预防和阻断病毒附着而具有强大的抗流感 (anti-influenza) 活性。Clemastanin B 靶向病毒内吞作用、脱壳或核糖核蛋白 (RNP) 从细胞核输出。Clemastanin B 具有抗氧化和抗炎活性。
生物活性

Clemastanin B, a lignin, has potentanti-influenzaactivities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities[1][2][3].

体外研究
(In Vitro)

Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC500.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV)[1].
Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells[1].
Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells[1].
Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus[1].

分子量

684.68

Formula

C32H44O16

CAS 号

112747-98-5

中文名称

直铁线莲宁B

结构分类
  • Phenylpropanoids
  • Lignans
来源
  • Plants
  • Cruciferae
  • Isatis tinctoriaL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.