生物活性
Moroxydine hydrochloride is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. Structurally moroxydine is a heterocyclic biguanidine.It possesses antiviral activity and is of value in the prevention and treatment of influenza. Although its mechanism of action is not fully known the effects seem to be due to an influence on the virus host-cell system. Oral medication has been shown to be effective against influenza, and small doses taken over a period of time have been shown to protect animals against influenza and other viral conditions. After preliminary trials with intramuscular injections the oral form of medication has been proven to be equally effective: pain usually disappears after two days, temperature reaches normal values and the lesion ceases to spread.
化学数据
| 分子量 | 207.66 |
| 分子式 | C6H13N5O.HCl |
| CAS号 | 3160-91-6 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO 40 mg/mL |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存
常温运输及临时存放 |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.8156 mL | 24.0778 mL | 48.1556 mL |
| 5 mM | 0.9631 mL | 4.8156 mL | 9.6311 mL |
| 10 mM | 0.4816 mL | 2.4078 mL | 4.8156 mL |
m.cnreagent.com