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IFN alpha-IFNAR-IN-1(IFN-alpha and IFNAR interaction inhibitor)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IFN alpha-IFNAR-IN-1(IFN-alpha and IFNAR interaction inhibitor)图片
CAS NO:844882-93-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
IFN α-IFNAR-IN-1（IFN-α 和 IFNAR 相互作用抑制剂）是一种非肽类、低分子量的 IFN-α 相互作用抑制剂；和 IFNAR；抑制 MVA 诱导的 IFN-α； BM-pDCs 的反应 (IC50=2-8 uM)。
Cas No.844882-93-5
Canonical SMILESCNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2
分子式C18H17NS
分子量279.4
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.