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CU-CPT-9a
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CU-CPT-9a图片
CAS NO:2165340-32-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CU-CPT-9a是TLR8的特异性拮抗剂，其IC50值为0.5nM。
Cas No.2165340-32-7
Canonical SMILESOC1=C(C)C=C(C=C1)C2=CC=NC3=CC(OC)=CC=C32
分子式C17H15NO2
分子量265.31
溶解度DMSO : 150 mg/mL (565.38 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases[1].

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.