| CAS NO: | 108237-91-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 108237-91-8 |
| Canonical SMILES | BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
| 分子式 | C15H11BrN2S |
| 分子量 | 331.23 |
| 溶解度 | DMSO : ≥ 160 mg/mL (483.05 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair. RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1]. RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1]. [1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769. |
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