| Cas No. | 73466-12-3 |
| 化学名 | 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester |
| Canonical SMILES | CCCCC/C=C\C/C=C\C=C\C=C\[C@H](O1)[C@@H]1CCCC(OC)=O |
| 分子式 | C21H32O3 |
| 分子量 | 332.5 |
| 溶解度 | Acetone: >50 mg/ml,DMF: >50 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: insoluble and unstable. |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed. |
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