您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Lipoxin B4
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Lipoxin B4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lipoxin B4图片
CAS NO:98049-69-5
包装与价格：
包装价格(元)
25μg电议
50μg电议
100μg电议

产品介绍
Cas No.98049-69-5
化学名5S,14R,15S-trihydroxy-6E,8Z,10E,12E-eicosatetraenoic acid
Canonical SMILESO[C@@H](CCCC(O)=O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCCC
分子式C20H32O5
分子量352.5
溶解度DMF: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.

References:
[1]. Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B Proc. Nat. Acad. Sci. USA 83(7), 1983-1987 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells Journal of Immunology 156, 2264-2272 (1996).