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Walrycin B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Walrycin B图片
CAS NO:878419-78-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Walrycin B 是一种新型抗菌化合物，专门针对必需的 WalR 反应调节剂。
Cas No.878419-78-4
化学名1,6-dimethyl-3-(4-(trifluoromethyl)phenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Canonical SMILESCN1C(C(C2=NC1=O)=NC(C3=CC=C(C(F)(F)F)C=C3)=NN2C)=O
分子式C14H10F3N5O2
分子量337.26
溶解度≥ 33.7mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Walrycin B is an inhibitor of WalR [1].

Walrycin B is screened out from a chemical library. It is proved to be a selective WalR inhibitor by measuring EGFP fluorescence intensity. In this assay, it is found to strongly increase fluorescence intensity in strain JM109/pFI014 but has no significant effect on the strain JM109/pFI001. Walrycin B shows effects on the expression of WalR regulon genes in the in vivo assay. The addition of it lowers the expression of ydjM, yocH and yvcE and increases the expression of yoeB and yjeA rapidly. These effects caused by Walrycin B are opposite with which caused by WalR suggesting that Walrycin B specifically affects the WalK/WalR system. Since WalK/WalR plays a regulating role in cell wall metabolism and cell division in Bacillus subtilis and Staphylococcus aureus, Walrycin B is found to cause cell death in both of them with strong MICs through targeting WalR [1].

References:
[1] Gotoh Y, Doi A, Furuta E, Dubrac S, Ishizaki Y, Okada M, Igarashi M, Misawa N, Yoshikawa H, Okajima T, Msadek T, Utsumi R. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo). 2010 Mar;63(3):127-34.