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Ethambutol HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ethambutol HCl图片
CAS NO:1070-11-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Ethambutol HCl (Emb dihydrochloride) 是一种抑菌抗分枝杆菌剂,通过抑制阿拉伯糖基转移酶来阻碍细胞壁的形成。
Cas No.1070-11-7
别名盐酸乙胺丁醇; Emb dihydrochloride
化学名2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol;dihydrochloride
Canonical SMILESCCC(CO)NCCNC(CC)CO.Cl.Cl
分子式C10H24N2O2.2HCl
分子量277.23
溶解度≥ 12.65mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nocodazole is a tubulin production inhibitor, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 value of 0.21 μM, 0.53 μM and 0.64 μM, respectively  [1].
Nocodazole is an inhibitor of microtubule polymerization which inhibits insulin-stimulated glucose transport. It impairs the morphology and directionality of migrating medial gan-glionic eminence cells and disrupts microtubules by binding to β-tubulin. Nocodazole also prevents the formation of one of the two interchain disulfide linkages and impairs the transport of vesicles.
As a high-affinity ligand for the cancer-related kinases such as Abl phosphorylated, c-Kit, BRAF, and MEK, nocodazole inhibits BRAF, Abl phosphorylated, c-Kit and MEK with Kd value of 1.8 μM, 0.091 μM, 1.6 μM, and 1.6 μM, respectively. Additionally, nocodazole inhibits phosphorylated Abl(E255K), phosphorylated  Abl(T315I), BRAF(V600E) and PI3Kγ with the Kd value of 0.12 μM, 0.17 μM, 1.1 μM and 1.5 μM, respectively. Mitotic cells which incubated with different concentrations of paclitaxel, released from the nocodazole block, are inhibited from progressing to G1 phase in 6 hours with a median inhibitory concentration of 4 nM. In the absence of nocodazole, the cells which pretreated with nocodazole exposed to paclitaxel only form free-floating microtubules, while pretreated cells exposed to paclitaxel organized microtubules [1,2].
In vivo, the therapeutic efficacy of a treatment of combination of nocodazole (5 mg/kg/three times per week) and ketoconazole (50 mg/kg/three times per week) was tested by treating athymic mice bearing COLO 205 tumor xenografts. The antitumor effects of nocodazole were significantly potentiated by ketoconazole in mice after 6 wk of treatment. The tumor volume and tumor weight of the mice treated with a combination of ketoconazole and nocodazole are significantly reduced as compared with those treated with ketoconazole or nocodazole alone. Treatment with the combination of ketoconazole and nocodazole strongly enhances apoptosis of COLO 205 tumor xenografts treated with nocodazole or ketoconazole alone [3].
References:
[1]. Park H, Hong S, Hong S. Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem, 2012, 7(1): 53-56.
[2]. Long bh,fairchild cr. Paclitaxel inhibits progression of mitotic cells to g(1) phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Research, 1994, 54(16): 4355-4361.
[3]. Wang YJ, Jeng JH, Chen RJ, et al. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Molecular Carcinogenesis, 2002, 34(4): 199-210.