包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
25mg | 电议 |
100mg | 电议 |
Cell lines | HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture |
Preparation method | The solubility of this compound in DMSO is >36.6 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
Reacting condition | EC50: 9 to 146 pM |
Applications | BMS-790052 exhibited picomolar half-maximum effective concentrations towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture, with EC50 values ranging from 9 to 146 pM. BMS-790052 displayed similar potency in Huh-7, HeLa and HEK293T cells. |
Animal models | patients chronically infected with HCV |
Dosage form | Oral administration, 10-100 mg |
Application | BMS-790052 was safe and well tolerated in HCV-infected subjects after single oral doses up to 100 mg. In HCV-infected subjects, BMS-790052 had a mean plasma elimination half-life ranging from 10 to 14 h. Administration of a single 100-mg dose of BMS-790052 was associated with a 3.3log 10 reduction in mean viral load measured 24h post-dose that was sustained for an additional 120h in two patients infected with genotype 1b virus. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
产品描述 | Daclatasvir, formerly known as BMS-790052, is a potent NS5A inhibitor with EC50 values varying from 9 to 146 pM. [1,2] |