Nitrofurantoin sodium 是一种口服有效的抗菌剂 (antibacterial agent)。Nitrofurantoin sodium 是一种抗生素 (antibiotic)。Nitrofurantoin sodium 可用于尿路感染 (UTIs) 的研究，包括膀胱炎和肾脏感染。
| 生物活性 | Nitrofurantoin sodium is a potent and orally activeantibacterialagent. Nitrofurantoin sodium acts as anantibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1][2]. |
体外研究
(In Vitro) | Nitrofurantoin sodium (0-512 mg/L; 8 h) treatment inhibits the growth ofE. coliisolates[3].
Cell Viability Assay[3] | Cell Line: | E. coliisolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627 | | Concentration: | 0, 32, 64, 128, 256, and 512 mg/L | | Incubation Time: | 8 hours | | Result: | Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627. |
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体内研究
(In Vivo) | 1.19Nitrofurantoin pharmacokinetic effects in SD Rats[4]. | Parameters | 10 mg/kg p.o. | 2 mg/kg i.v. | | AUC0-720(μg/mLomin) | 306 | | | AUC0-120(μg/mLomin) | | 90.3 | | AUC0-∞(μg/mLomin) | 344 | 91.5 | | Cmax(μg/mL) | 1.01 | | | CL/F or CL (ml/min/kg) | 31.0 | 22.7 | | t1/2(min) | 166 | 23.6 | | Bioavailability (%) | 60.1 | | |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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