Cefazolin sodium pentahydrate 是第一代头孢菌素类抗生素，可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用，可以减轻术后认知功能障碍 (POCD)。
| 生物活性 | Cefazolin sodium pentahydrate is a first-generationcephalosporinantibioticand can be used in varieties ofbacterialinfections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2]. |
体外研究
(In Vitro) | Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide[2].
Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation[3].
Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation[3].
Cell Viability Assay[2] | Cell Line: | C8-B4 cells | | Concentration: | 0, 50, 100, 150, 200, 250, or 300 μg/ml | | Incubation Time: | 6 or 24 hours | | Result: | Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml. |
Cell Proliferation Assay[3] | Cell Line: | PBMC, and TF-1 cells | | Concentration: | 0, 100, 200, and 400 μM | | Incubation Time: | 72 hours | | Result: | Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc. |
Western Blot Analysis[3] | Cell Line: | PBMC, NK-92, and TF-1 cells | | Concentration: | 0, 100, 200, and 400 μM | | Incubation Time: | 30 min | | Result: | Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γcreceptors. |
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体内研究
(In Vivo) | Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery[2].
| Animal Model: | 6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy[2] | | Dosage: | 300-500 mg/kg | | Administration: | Subcutaneous injection; 300-500 mg/kg; once daily; 5 days | | Result: | Attenuated learning and memory dysfunction induced by the surgery. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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