Cefpiramide

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Cefpiramide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

70797-11-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

SM-1652 free acid
Wy-44635 free acid

产品介绍

Cefpiramide (SM-1652) free acid 是一种半合成头孢菌素，具有广谱抗菌活性。Cefpiramide free acid 对革兰氏阳性细菌和革兰氏阴性细菌均具有很强的抗菌活性。Cefpiramide free acid 对 β-内酰胺酶具有中度敏感性。

生物活性

Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase^[1]^[2].

IC₅₀& Target

Bacterial^[1]^[2]

体外研究
(In Vitro)

Cefpiramide (0-2048 μg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli andEnterococci(32 μg/mL with 97% inhibition)^[1].
Cefpiramide (0-2048 μg/mL; 16-18 hours) exhibits high effective to againstPseudomonas aeruginosawith MIC_[50]and MIC_[90]values of 4 μg/mL and 16 μg/mL separately^[1].

Cell Viability Assay^[1]

Cell Line:	761 bacterial isolates (35 different species of common bacterial pathogens)
Concentration:	0-2048 μg/mL
Incubation Time:	16-18 hours
Result:	Showed broad-spectrum antibacterial activity.

体内研究
(In Vivo)

Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniaeactivity in experimental pneumococcal meningitis^[2].
Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10^[4]CFU/ml^[2].

Animal Model:	New Zealand white male rabbits(2-3 kg)^[2].
Dosage:	25 mg/kg
Administration:	Intravenous injection; once.
Result:	Anti-Streptococcus pneumoniae.

分子量

612.64

Formula

C₂₅H₂₄N₈O₇S₂

CAS 号

70797-11-4

中文名称

头孢匹胺游离酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.